Double-Blind Comparison of First- and Second-Generation Antipsychotics in Early-Onset Schizophrenia and Schizo-affective Disorder: Findings From the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study
Double-Blind Maintenance Safety and Effectiveness Findings From the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) Study
"Of the 116 youths randomized in the acute trial, 54 entered maintenance treatment (molindone, n = 20; olanzapine, n = 13; risperidone, n = 21). Fourteen (26%) completed 44 weeks of treatment."
Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS): Demographic and Clinical Characteristics
"From February 2002 to May 2006, 476 youths were screened, 173 were further evaluated, and 119 were randomized"
the following is a literature review study, not an article specific to the TEOSS drug trial.
Efficacy and Tolerability of Second-Generation Antipsychotics in Children and Adolescents With Schizophrenia
Hooper SR, Giuliano AJ, Youngstrom EA, Breiger D, Sikich L, Frazier JA, Findling RL, McClellan J, Hamer RM, Vitiello B, Lieberman JA.
J Am Acad Child Adolesc Psychiatry. 2010 Jan;49(1):52-60.
- [PubMed - indexed for MEDLINE]
Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics
Frazier JA, McClellan J, Findling RL, Vitiello B, Anderson R, Zablotsky B, Williams E, McNamara NK, Jackson JA, Ritz L, Hlastala SA, Pierson L, Varley JA, Puglia M, Maloney AE, Ambler D, Hunt-Harrison T, Hamer RM, Noyes N, Lieberman JA, Sikich L.
Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study.
Findling RL, Johnson JL, McClellan J, Frazier JA, Vitiello B, Hamer RM, Lieberman JA, Ritz L, McNamara NK, Lingler J, Hlastala S, Pierson L, Puglia M, Maloney AE, Kaufman EM, Noyes N,Sikich L. "Of the 116 youths randomized in the acute trial, 54 entered maintenance treatment"
Disorder: Findings From the Treatment of Early-
Onset Schizophrenia Spectrum Disorders (TEOSS) Study pdf download
Results: "In total, 119 youth were randomly assigned to treatment. Of these subjects, 116 received at least one dose of treatment and thus were available for analysis."
Discussion a couple of excerpts:
"Second-generation antipsychotics olanzapine and risperidone did not demonstrate superior efficacy to molindone in the treatment of children and adolescents with early-onset schizophrenia and schizoaffective disorder. Across all three treatments, more than half the participants failed to achieve an adequate response after 8 weeks of therapy."
"At the time the study was initiated, there were significant ethical concerns about utilizing any first-generation antipsychotic in comparison with second-generation antipsychotics, because second-generation antipsychotic treatment was the standard of care for early-onset schizophrenia and schizoaffective disorder."
The above sentence begs the question, "WHY are SGAs considered the Standard of Care? What the hell is this supposed "standard" based on?!
via Find the Data:
Start Date: 02/01/2002
Completion Date: 05/01/2007